Indication & Dosage |
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| Intravenous |
| NOSOCOMIAL PNEUMONIA |
| Adult:
Initial doses: 4.5 g every 6 hr (total dose in 24 hr: 16 g piperacillin/2 g tazobactam) plus an aminoglycoside. May be given via bolus inj over 3-5 min or infusion over 20-30 min. If Pseudomonas aeruginosa is isolated, continue treatment with the aminoglycoside. If not, the aminoglycoside may be discontinued. Recommended treatment duration: 7-14 days. |
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| Intravenous |
| SUSCEPTIBLE INFECTIONS EXCEPT NOSOCOMIAL PNEUMONIA |
| Adult:
Mild infections: 2/0.25 g every 6-12 hr. Severe infections: 4/0.5 g every 6-8 hr. May be given as bolus inj over 3-5 min or infusion over 20-30 min. Recommended treatment duration: 7-10 days. |
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| Precautions |
Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment. |
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Potentially Life-threatening
Adverse Drug Reactions |
Diarrhoea, skin rashes, occasionally platelet mediated bleeding, rigors, malaise, ulcerative stomatitis. Inj-site reactions such as pain, erythema, induration and thrombophlebitis. |
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| Adverse Drug Reactions |
Serious, anaphylactic reactions. |
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| Interactions |
Interacts with heparin and other oral anticoagulants. Prolongs the neuromuscular blockade of vecuronium and non-depolarizing muscle relaxants. Probenecid prolongs half lives of piperacillin and tazobactam. Increased risk of methotrexate toxicity when used together. |
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